/* ==========================================================================
   Activome Therapeutics, Inc. — site styles
   Design language: warm near-monochrome, disciplined grid, spacious pacing.
   Serif (Newsreader) is used ONLY on the homepage hero headline.
   Sans (Libre Franklin) carries everything else. Mono (IBM Plex Mono) is a
   utility face for eyebrow labels and pipeline metadata.
   Single accent: muted bronze, used sparingly.
   --------------------------------------------------------------------------
   HOW TO EDIT COLORS / TYPE: change the custom properties in :root below.
   ========================================================================== */

:root {
  /* --- Palette (warm near-monochrome + one bronze accent) --- */
  --paper:        #F5F2EC;  /* page background (warm paper) */
  --paper-raise:  #FBF9F5;  /* raised surfaces: nav, cards */
  --paper-deep:   #EDE8DF;  /* alternate section background */
  --ink:          #211F1B;  /* primary text (warm graphite) */
  --ink-soft:     #55514A;  /* secondary text */
  --ink-faint:    #8A857C;  /* muted meta text */
  --line:         #E1DACE;  /* hairline borders */
  --line-strong:  #CFC6B6;  /* stronger dividers */
  --bronze:       #8A6A43;  /* accent for rules / motif / large marks */
  --bronze-deep:  #6E5334;  /* accent for small text, labels, links (AA) */
  --bronze-tint:  #EEE6D6;  /* very light bronze wash (rare) */

  /* --- Type --- */
  --font-serif: "Newsreader", Georgia, "Times New Roman", serif;
  --font-sans:  "Libre Franklin", system-ui, -apple-system, "Segoe UI", Roboto, Helvetica, Arial, sans-serif;
  --font-mono:  "IBM Plex Mono", ui-monospace, "SFMono-Regular", Menlo, Consolas, monospace;

  /* --- Layout --- */
  --maxw: 1120px;
  --gutter: clamp(1.25rem, 4vw, 2.5rem);
  --radius: 4px;

  --focus: #6E5334;
}

/* --------------------------------- Reset --------------------------------- */
*, *::before, *::after { box-sizing: border-box; }
html { -webkit-text-size-adjust: 100%; scroll-behavior: smooth; }
@media (prefers-reduced-motion: reduce) { html { scroll-behavior: auto; } }

body {
  margin: 0;
  background: var(--paper);
  color: var(--ink);
  font-family: var(--font-sans);
  font-size: 1.0625rem;          /* 17px */
  line-height: 1.7;
  font-weight: 400;
  letter-spacing: 0.005em;
  -webkit-font-smoothing: antialiased;
  text-rendering: optimizeLegibility;
}

img, svg { display: block; max-width: 100%; }
h1, h2, h3, h4, p, ul, ol { margin: 0; }
ul { padding: 0; list-style: none; }

/* ------------------------------- Utilities ------------------------------- */
.wrap {
  width: 100%;
  max-width: var(--maxw);
  margin-inline: auto;
  padding-inline: var(--gutter);
}
.measure { max-width: 62ch; }
.measure-tight { max-width: 52ch; }
.sr-only {
  position: absolute; width: 1px; height: 1px; padding: 0; margin: -1px;
  overflow: hidden; clip: rect(0 0 0 0); white-space: nowrap; border: 0;
}

/* Skip link */
.skip-link {
  position: absolute; left: 1rem; top: -3rem; z-index: 100;
  background: var(--ink); color: var(--paper);
  padding: 0.6rem 1rem; border-radius: var(--radius);
  transition: top 0.15s ease;
}
.skip-link:focus { top: 1rem; }

/* Visible keyboard focus everywhere */
a:focus-visible, button:focus-visible, input:focus-visible,
select:focus-visible, textarea:focus-visible {
  outline: 2px solid var(--focus);
  outline-offset: 2px;
  border-radius: 2px;
}

/* --------------------------------- Type ---------------------------------- */
.eyebrow {
  font-family: var(--font-mono);
  font-size: 0.72rem;
  letter-spacing: 0.18em;
  text-transform: uppercase;
  color: var(--bronze-deep);
  font-weight: 500;
  margin-bottom: 1.1rem;
  display: inline-flex;
  align-items: center;
  gap: 0.7rem;
}
.eyebrow::before {
  content: "";
  width: 1.6rem; height: 1px;
  background: var(--bronze);
  display: inline-block;
}

h2.section-title {
  font-family: var(--font-sans);
  font-weight: 500;
  font-size: clamp(1.55rem, 3.2vw, 2.15rem);
  line-height: 1.2;
  letter-spacing: -0.015em;
  color: var(--ink);
  max-width: 22ch;
}
h3.sub-title {
  font-family: var(--font-sans);
  font-weight: 500;
  font-size: 1.15rem;
  line-height: 1.35;
  letter-spacing: -0.01em;
  color: var(--ink);
}
.lead {
  font-size: clamp(1.1rem, 2vw, 1.3rem);
  line-height: 1.55;
  color: var(--ink-soft);
  font-weight: 400;
}
p + p { margin-top: 1.1rem; }
.prose p { color: var(--ink-soft); }
.prose p strong { color: var(--ink); font-weight: 500; }

/* Text links inside body copy */
.prose a, .link {
  color: var(--ink);
  text-decoration: none;
  border-bottom: 1px solid var(--bronze);
  transition: color 0.15s ease, border-color 0.15s ease;
}
.prose a:hover, .link:hover { color: var(--bronze-deep); border-color: var(--bronze-deep); }

/* -------------------------------- Buttons -------------------------------- */
.btn {
  display: inline-flex; align-items: center; gap: 0.6rem;
  font-family: var(--font-sans);
  font-size: 0.92rem; font-weight: 500; letter-spacing: 0.01em;
  padding: 0.85rem 1.4rem;
  border-radius: var(--radius);
  text-decoration: none;
  cursor: pointer;
  transition: background 0.15s ease, color 0.15s ease, border-color 0.15s ease, transform 0.05s ease;
  border: 1px solid transparent;
}
.btn:active { transform: translateY(1px); }
.btn--primary { background: var(--ink); color: var(--paper); }
.btn--primary:hover { background: #000; }
.btn--ghost { background: transparent; color: var(--ink); border-color: var(--line-strong); }
.btn--ghost:hover { border-color: var(--ink); }
.btn .arrow { transition: transform 0.15s ease; }
.btn:hover .arrow { transform: translateX(3px); }

/* -------------------------------- Header --------------------------------- */
.site-header {
  position: sticky; top: 0; z-index: 50;
  background: var(--paper); /* fallback for browsers without color-mix */
  background: color-mix(in srgb, var(--paper) 88%, transparent);
  -webkit-backdrop-filter: blur(8px); backdrop-filter: blur(8px);
  border-bottom: 1px solid var(--line);
}
.header-inner {
  display: flex; align-items: center; justify-content: space-between;
  min-height: 72px;
}
.brand { display: inline-flex; align-items: center; gap: 0.7rem; text-decoration: none; color: var(--ink); }
.brand-mark { width: 26px; height: 26px; flex: none; }
.brand-name { font-size: 1.02rem; letter-spacing: -0.01em; white-space: nowrap; }
.brand-name strong { font-weight: 600; }
.brand-name span { color: var(--ink-soft); font-weight: 400; }

.site-nav { display: flex; align-items: center; }
.nav-menu { display: flex; align-items: center; gap: 0.35rem; }
.nav-menu a {
  display: inline-block;
  font-size: 0.95rem; font-weight: 400;
  color: var(--ink-soft); text-decoration: none;
  padding: 0.5rem 0.85rem; border-radius: var(--radius);
  transition: color 0.15s ease, background 0.15s ease;
}
.nav-menu a:hover { color: var(--ink); background: var(--paper-deep); }
.nav-menu a[aria-current="page"] { color: var(--ink); }
.nav-menu a[aria-current="page"]::after {
  content: ""; display: block; height: 1px; margin-top: 3px;
  background: var(--bronze);
}
.nav-menu a.nav-cta {
  color: var(--ink); border: 1px solid var(--line-strong);
  margin-left: 0.5rem;
}
.nav-menu a.nav-cta:hover { border-color: var(--ink); background: transparent; }

.nav-toggle { display: none; }

/* --------------------------------- Hero ---------------------------------- */
.hero { position: relative; overflow: hidden; }
.hero-inner {
  padding-block: clamp(4.5rem, 11vw, 9rem);
  display: grid;
  grid-template-columns: minmax(0, 1.15fr) minmax(0, 0.85fr);
  gap: clamp(2rem, 5vw, 4.5rem);
  align-items: center;
}
.hero-headline {
  font-family: var(--font-serif);          /* SERIF — homepage hero only */
  font-weight: 400;
  font-size: clamp(2.4rem, 6vw, 4.1rem);
  line-height: 1.06;
  letter-spacing: -0.02em;
  color: var(--ink);
  max-width: 15ch;
}
.hero-sub {
  margin-top: 1.6rem;
  font-size: clamp(1.05rem, 1.8vw, 1.22rem);
  line-height: 1.6;
  color: var(--ink-soft);
  max-width: 46ch;
}
.hero-actions { margin-top: 2.2rem; display: flex; flex-wrap: wrap; gap: 0.9rem; }
.hero-figure { position: relative; }
.hero-figure svg { width: 100%; height: auto; }

/* -------------------------------- Sections ------------------------------- */
.section { padding-block: clamp(4rem, 9vw, 7.5rem); }
.section--tight { padding-block: clamp(3rem, 6vw, 5rem); }
.section--divider { border-top: 1px solid var(--line); }
.section--deep { background: var(--paper-deep); }

.section-head { max-width: 60ch; margin-bottom: clamp(2rem, 4vw, 3rem); }
.section-head .lead { margin-top: 1.1rem; }

/* Two-column editorial split */
.split {
  display: grid;
  grid-template-columns: minmax(0, 0.9fr) minmax(0, 1.1fr);
  gap: clamp(2rem, 5vw, 4.5rem);
  align-items: start;
}
.split--even { grid-template-columns: 1fr 1fr; }

/* Feature grid / cards */
.grid { display: grid; gap: clamp(1.5rem, 3vw, 2.5rem); }
.grid--2 { grid-template-columns: repeat(2, minmax(0, 1fr)); }
.grid--3 { grid-template-columns: repeat(3, minmax(0, 1fr)); }

.card {
  background: var(--paper-raise);
  border: 1px solid var(--line);
  border-radius: 10px;
  padding: clamp(1.5rem, 2.5vw, 2rem);
}
.card .card-index {
  font-family: var(--font-mono);
  font-size: 0.72rem; letter-spacing: 0.14em;
  color: var(--bronze-deep); text-transform: uppercase;
  display: block; margin-bottom: 1rem;
}
.card h3 { margin-bottom: 0.6rem; }
.card p { color: var(--ink-soft); font-size: 0.98rem; }

/* Plain list of focus areas (no cards) */
.deflist { display: grid; gap: 0; }
.deflist > div {
  display: grid;
  grid-template-columns: minmax(0, 0.4fr) minmax(0, 1fr);
  gap: clamp(1rem, 3vw, 2.5rem);
  padding: 1.6rem 0;
  border-top: 1px solid var(--line);
}
.deflist > div:last-child { border-bottom: 1px solid var(--line); }
.deflist dt { font-weight: 500; color: var(--ink); }
.deflist dd { margin: 0; color: var(--ink-soft); }

/* Small stat / metric row */
.facts { display: grid; grid-template-columns: repeat(3, 1fr); gap: clamp(1.5rem,3vw,2.5rem); }
.fact .fact-label {
  font-family: var(--font-mono); font-size: 0.7rem; letter-spacing: 0.14em;
  text-transform: uppercase; color: var(--bronze-deep); margin-bottom: 0.6rem;
}
.fact .fact-value { font-size: 1.05rem; color: var(--ink); font-weight: 400; line-height: 1.4; }

/* ------------------------------- Pipeline -------------------------------- */
.pipeline-table {
  width: 100%; border-collapse: collapse; margin-top: 1rem;
  font-size: 0.95rem;
}
.pipeline-table thead th {
  text-align: left; font-family: var(--font-mono);
  font-size: 0.68rem; letter-spacing: 0.14em; text-transform: uppercase;
  color: var(--ink-faint); font-weight: 500;
  padding: 0 1rem 0.9rem 0; border-bottom: 1px solid var(--line-strong);
}
.pipeline-table tbody td {
  padding: 1.4rem 1rem 1.4rem 0; border-bottom: 1px solid var(--line);
  vertical-align: top; color: var(--ink-soft);
}
.pipeline-table tbody td:first-child { color: var(--ink); font-weight: 500; }
.stage {
  display: inline-flex; align-items: center; gap: 0.5rem;
  font-family: var(--font-mono); font-size: 0.72rem; letter-spacing: 0.08em;
  text-transform: uppercase; color: var(--bronze-deep);
  padding: 0.3rem 0.65rem; border: 1px solid var(--line-strong); border-radius: 999px;
  white-space: nowrap;
}
.stage::before { content: ""; width: 6px; height: 6px; border-radius: 50%; background: var(--bronze); }

/* Program card (alternate presentation for a single lead program) */
.program {
  background: var(--paper-raise); border: 1px solid var(--line);
  border-radius: 10px; padding: clamp(1.75rem, 3vw, 2.5rem);
}
.program-head {
  display: flex; flex-wrap: wrap; gap: 1rem; align-items: baseline;
  justify-content: space-between; margin-bottom: 1.5rem;
}
.program-head h3 { font-size: 1.35rem; }
.program-grid {
  display: grid; grid-template-columns: repeat(auto-fit, minmax(160px, 1fr));
  gap: 1.5rem; border-top: 1px solid var(--line); padding-top: 1.5rem;
}
.program-grid dt {
  font-family: var(--font-mono); font-size: 0.68rem; letter-spacing: 0.14em;
  text-transform: uppercase; color: var(--ink-faint); margin-bottom: 0.5rem;
}
.program-grid dd { margin: 0; color: var(--ink); font-size: 0.98rem; }

/* Progress bar for stage (very restrained) */
.stage-bar { margin-top: 0.7rem; height: 3px; background: var(--line); border-radius: 999px; overflow: hidden; }
.stage-bar > span { display: block; height: 100%; background: var(--bronze); }

/* Discrete development-stage track (industry-standard phases) */
.phase-scroll { overflow-x: auto; }
.phase-track ol { display: flex; min-width: 460px; margin: 0; padding: 0; }
.phase-track li { flex: 1; position: relative; padding-top: 18px; list-style: none; }
.phase-track li .dot {
  position: absolute; top: 1px; left: 0; width: 12px; height: 12px; border-radius: 50%;
  background: var(--paper-raise); border: 2px solid var(--line-strong); box-sizing: border-box;
}
.phase-track li::after {
  content: ""; position: absolute; top: 6px; left: 12px; right: 0; height: 2px; background: var(--line-strong);
}
.phase-track li:last-child::after { display: none; }
.phase-track li .phase-label {
  display: block; font-family: var(--font-mono); font-size: 0.62rem; letter-spacing: 0.1em;
  text-transform: uppercase; color: var(--ink-faint);
}
.phase-track li.is-done .dot,
.phase-track li.is-current .dot { background: var(--bronze); border-color: var(--bronze); }
.phase-track li.is-current .dot { box-shadow: 0 0 0 3px var(--bronze-tint); }
.phase-track li.is-done::after { background: var(--bronze); }
.phase-track li.is-done .phase-label,
.phase-track li.is-current .phase-label { color: var(--bronze-deep); }

/* ------------------------------ Callout / note --------------------------- */
.note {
  border-left: 2px solid var(--bronze);
  border-radius: 0;
  padding: 0.4rem 0 0.4rem 1.4rem;
  color: var(--ink-soft);
  font-size: 0.95rem;
}
.note strong { color: var(--ink); font-weight: 500; }

/* --------------------------------- Forms --------------------------------- */
.form { max-width: 640px; }
.field { margin-bottom: 1.4rem; }
.field label {
  display: block; font-size: 0.85rem; font-weight: 500; color: var(--ink);
  margin-bottom: 0.5rem;
}
.field .req { color: var(--bronze-deep); }
.field input, .field select, .field textarea {
  width: 100%; font-family: var(--font-sans); font-size: 1rem; color: var(--ink);
  background: var(--paper-raise);
  border: 1px solid var(--line-strong); border-radius: var(--radius);
  padding: 0.8rem 0.9rem; line-height: 1.5;
  transition: border-color 0.15s ease, box-shadow 0.15s ease;
}
.field textarea { min-height: 150px; resize: vertical; }
.field input:hover, .field select:hover, .field textarea:hover { border-color: var(--ink-faint); }
.field input:focus, .field select:focus, .field textarea:focus {
  outline: none; border-color: var(--bronze-deep);
  box-shadow: 0 0 0 3px var(--bronze-tint);
}
.field-row { display: grid; grid-template-columns: 1fr 1fr; gap: 1.2rem; }
.form-actions { margin-top: 1.8rem; display: flex; align-items: center; gap: 1rem; flex-wrap: wrap; }
.form-consent { font-size: 0.85rem; color: var(--ink-faint); max-width: 46ch; }

/* -------------------------------- Footer --------------------------------- */
.site-footer { border-top: 1px solid var(--line); background: var(--paper-deep); }
.footer-grid {
  display: grid;
  grid-template-columns: minmax(0, 1.4fr) minmax(0, 1fr) minmax(0, 1fr);
  gap: clamp(2rem, 5vw, 4rem);
  padding-block: clamp(3rem, 6vw, 4.5rem);
}
.footer-tagline { color: var(--ink-soft); margin-top: 1rem; max-width: 34ch; font-size: 0.98rem; }
.footer-col h4 {
  font-family: var(--font-mono); font-size: 0.68rem; letter-spacing: 0.14em;
  text-transform: uppercase; color: var(--ink-faint); font-weight: 500; margin-bottom: 1.1rem;
}
.footer-col ul { display: grid; gap: 0.65rem; }
.footer-col a { color: var(--ink-soft); text-decoration: none; font-size: 0.95rem; }
.footer-col a:hover { color: var(--ink); }
.footer-legal {
  border-top: 1px solid var(--line); padding-block: 1.75rem 2.5rem;
  display: grid; gap: 1rem;
}
.footer-legal .disclaimer { font-size: 0.8rem; color: var(--ink-faint); line-height: 1.65; max-width: 92ch; }
.footer-legal .copyright { font-size: 0.8rem; color: var(--ink-faint); }
.footer-legal .copyright a { color: var(--ink-soft); text-decoration: none; }
.footer-legal .copyright a:hover { color: var(--ink); }

/* --------------------------- Page intro (interior) ----------------------- */
.page-intro { padding-block: clamp(3.5rem, 8vw, 6rem) clamp(2rem, 4vw, 3rem); }
.page-intro h1 {
  font-family: var(--font-sans); font-weight: 500;
  font-size: clamp(2rem, 5vw, 3.1rem); line-height: 1.1; letter-spacing: -0.02em;
  color: var(--ink); max-width: 18ch;
}
.page-intro .lead { margin-top: 1.4rem; max-width: 54ch; }

/* -------------------------------- Motion --------------------------------- */
/* Content is only hidden when JS is present (html.js). Without JS — or for
   crawlers — everything renders normally. */
.js .reveal { opacity: 0; transform: translateY(14px); }
.js .reveal.is-in { opacity: 1; transform: none; transition: opacity 0.7s ease, transform 0.7s ease; }
@media (prefers-reduced-motion: reduce) {
  .js .reveal { opacity: 1 !important; transform: none !important; transition: none !important; }
}

/* ------------------------------ Responsive ------------------------------- */
@media (max-width: 860px) {
  .hero-inner { grid-template-columns: 1fr; gap: 2.5rem; }
  .hero-figure { max-width: 300px; margin-inline: auto; }
  .split, .split--even { grid-template-columns: 1fr; }
  .grid--3 { grid-template-columns: 1fr 1fr; }
  .footer-grid { grid-template-columns: 1fr 1fr; }
  .footer-brand { grid-column: 1 / -1; }
}

@media (max-width: 640px) {
  .grid--2, .grid--3 { grid-template-columns: 1fr; }
  .facts { grid-template-columns: 1fr; gap: 1.5rem; }
  .field-row { grid-template-columns: 1fr; }
  .deflist > div { grid-template-columns: 1fr; gap: 0.4rem; }
  .footer-grid { grid-template-columns: 1fr; }

  /* Mobile navigation */
  .nav-toggle {
    display: inline-flex; align-items: center; justify-content: center;
    width: 44px; height: 44px; background: transparent; border: 0; cursor: pointer;
    color: var(--ink);
  }
  .nav-toggle span, .nav-toggle span::before, .nav-toggle span::after {
    content: ""; display: block; width: 22px; height: 1.5px; background: currentColor;
    transition: transform 0.2s ease, opacity 0.2s ease;
  }
  .nav-toggle span { position: relative; }
  .nav-toggle span::before { position: absolute; top: -7px; }
  .nav-toggle span::after { position: absolute; top: 7px; }
  .nav-toggle[aria-expanded="true"] span { background: transparent; }
  .nav-toggle[aria-expanded="true"] span::before { transform: translateY(7px) rotate(45deg); }
  .nav-toggle[aria-expanded="true"] span::after { transform: translateY(-7px) rotate(-45deg); }

  .nav-menu {
    position: absolute; left: 0; right: 0; top: 100%;
    flex-direction: column; align-items: stretch; gap: 0;
    background: var(--paper-raise); border-bottom: 1px solid var(--line);
    padding: 0.5rem var(--gutter) 1.25rem;
    box-shadow: 0 12px 24px rgba(33, 31, 27, 0.06);
    display: none;
  }
  .nav-menu.is-open { display: flex; }
  .nav-menu a { padding: 0.85rem 0.25rem; font-size: 1rem; border-radius: 0; }
  .nav-menu a:hover { background: transparent; }
  .nav-menu a[aria-current="page"]::after { display: none; }
  .nav-menu a.nav-cta { margin-left: 0; margin-top: 0.6rem; border-radius: var(--radius); text-align: center; padding: 0.85rem; }
  .site-nav { position: static; }
}

/* --------------------------------- Print --------------------------------- */
@media print {
  :root { --paper: #fff; --paper-raise: #fff; --paper-deep: #fff; }
  body { background: #fff; color: #000; font-size: 11pt; line-height: 1.5; }
  .site-header, .nav-toggle, .hero-figure, .hero-actions, .skip-link,
  .form, .btn { display: none !important; }
  .site-footer { background: #fff; border-top: 1px solid #999; }
  .section, .section--deep, .section--divider, .page-intro, .hero { padding-block: 1.2rem; background: #fff; border: 0; }
  .card, .program { border: 1px solid #ccc; box-shadow: none; }
  .js .reveal { opacity: 1 !important; transform: none !important; }
  a { color: #000; text-decoration: underline; }
  .footer-legal .disclaimer { color: #333; }
  h1, h2, h3 { page-break-after: avoid; }
}